The Relationship between TLR3 rs3775291 Polymorphism and Infectious Diseases: A Meta-Analysis of Case-Control Studies

As the host’s first line of defense against pathogens, Toll-like receptors (TLRs), such as TLR3, are genes encoding transmembrane same name. Depending on their expression, TLRs cause a pro- or anti-inflammatory response. The purpose article was to determine whether there is an association between receptor 3 (TLR3) rs3775291 Single Nucleotide Polymorphism—SNP and susceptibility infections. This review conducted according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) 2020 guidelines registered in PROSPERO under code CRD42023429533. A systematic search relevant studies performed using PubMed, Scopus, SciELO, Google Scholar, Science Direct by MeSH descriptors Boolean Operator “AND”: “Infections”; “TLR3”; “SNP”, January 2005 July 2022. Summary odds ratios (ORs) corresponding 95% confidence intervals (CIs) were calculated genotypic comparison assuming dominant genetic model (CT + TT vs. CC). meta-analysis 18 consisting 3118 cases 4368 controls found significant risk presence TLR3 SNP infections part general analysis (OR = 1.16, CI 1.04–1.28, p 0.004). In subgroups continents, had protective role Europe 1044 1471 0.83, 0.70–0.99, 0.04); however, Asian (for 1588 patients 2306 controls) American 486 591 continents increase infectious 1.37, 1.19–1.58, < 0.001; OR 1.42, 1.08–1.86, 0.01, respectively). Heterogeneity detected (I2 58%) but explained meta-regression subgroup itself publication bias not evident. results suggest polymorphism Thus, when analyzing subgroups, showed that this confers higher model. Therefore, more necessary fully elucidate